|Other Names||Translocation protein SEC63 homolog, SEC63, SEC63L|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13128a was selected from the N-term region of SEC63. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed, with high levels in the liver.|
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Provided below are standard protocols that you may find useful for product applications.
The Sec61 complex is the central component of the proteintranslocation apparatus of the endoplasmic reticulum (ER) membrane.The protein encoded by this gene and SEC62 protein are found to beassociated with ribosome-free SEC61 complex. It is speculated thatSec61-Sec62-Sec63 may perform post-translational proteintranslocation into the ER. The Sec61-Sec62-Sec63 complex might alsoperform the backward transport of ER proteins that are subject tothe ubiquitin-proteasome-dependent degradation pathway. The encodedprotein is an integral membrane protein located in the rough ER.
Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)van Keimpema, L., et al. Liver Int. (2010) In press :Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008)You, K.T., et al. PLoS Biol. 5 (5), E109 (2007) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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