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MCL1 Antibody (BH3 Domain Specific) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q07820
Clone Names 2011203
Peptide ID 2011203
Additional Information
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1312a was selected from the region of human Mcl-1 BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCL1
Synonyms BCL2L3
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria
Research Areas
Citations (0)

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The Mcl-1 protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.


Crossley, L.J., J. Leukoc. Biol. 74(4):583-592 (2003).Kotelkin, A., et al., J. Virol. 77(17):9156-9172 (2003).Erwert, R.D., et al., Microb. Pathog. 35(2):87-93 (2003).Liu, H., et al., Blood 102(1):344-352 (2003).Nijhawan, D., et al., Genes Dev. 17(12):1475-1486 (2003).

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$ 80.00
Cat# BP1312a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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