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HOOK1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UJC3 |
|---|---|
| Clone Names | 100324147 |
| Gene ID | 51361 |
|---|---|
| Other Names | Protein Hook homolog 1, h-hook1, hHK1, HOOK1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13130c was selected from the Center region of HOOK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HOOK1 (HGNC:19884) |
|---|---|
| Function | Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa (By similarity) {ECO:0000250|UniProtKB:Q8BIL5} |
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Background
This gene encodes a member of the hook family ofcoiled-coil proteins, which bind to microtubules and organellesthrough their N- and C-terminal domains, respectively. The encodedprotein localizes to discrete punctuate subcellular structures, andinteracts with several members of the Rab GTPase family involved inendocytosis. It is thought to link endocytic membrane traffickingto the microtubule cytoskeleton. Several alternatively splicedtranscript variants have been identified, but the full-lengthnature of some of these variants has not been determined. [providedby RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Simpson, F., et al. Traffic 6(6):442-458(2005)
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