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REPS2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NFH8 |
|---|---|
| Clone Names | 100324150 |
| Gene ID | 9185 |
|---|---|
| Other Names | RalBP1-associated Eps domain-containing protein 2, Partner of RalBP1, RalBP1-interacting protein 2, REPS2, POB1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13131a was selected from the N-term region of REPS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | REPS2 |
|---|---|
| Synonyms | POB1 |
| Function | Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway (PubMed:9422736, PubMed:12771942, PubMed:10393179). By controlling growth factor receptors endocytosis may regulate cell survival (PubMed:12771942). Through ASAP1 may regulate cell adhesion and migration (PubMed:12149250). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney Isoform 2 is down-regulated during progression of prostate cancer |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is part of a protein complex thatregulates the endocytosis of growth factor receptors. The encodedprotein directly interacts with a GTPase activating protein thatfunctions downstream of the small G protein Ral. Its expression cannegatively affect receptor internalization and inhibit growthfactor signaling. Multiple transcript variants encoding differentisoforms have been found for this gene.
References
Doolan, P., et al. Tumour Biol. 30(4):200-209(2009)Singhal, S.S., et al. J. Biol. Chem. 283(28):19714-19729(2008)Yadav, S., et al. Biochem. Biophys. Res. Commun. 328(4):1003-1009(2005)Oosterhoff, J.K., et al. Int. J. Cancer 113(4):561-567(2005)Penninkhof, F., et al. Oncogene 23(33):5607-5615(2004)
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