LIMCH1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UPQ0 |
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Clone Names | 100405106 |
Gene ID | 22998 |
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Other Names | LIM and calponin homology domains-containing protein 1, LIMCH1, KIAA1102 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13141b was selected from the C-term region of LIMCH1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LIMCH1 (HGNC:29191) |
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Function | Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. |
Cellular Location | Cytoplasm, cytoskeleton, stress fiber |
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Provided below are standard protocols that you may find useful for product applications.
Background
LIMCH1 contains one CH (calponin-homology) domain and one LIM zinc-binding domain. There are nine named isoforms.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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