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SLC9A5 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14940 |
|---|---|
| Clone Names | 100405165 |
| Gene ID | 6553 |
|---|---|
| Other Names | Sodium/hydrogen exchanger 5, Na(+)/H(+) exchanger 5, NHE-5, Solute carrier family 9 member 5, SLC9A5, NHE5 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13149b was selected from the C-term region of SLC9A5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC9A5 (HGNC:11078) |
|---|---|
| Synonyms | NHE5 |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:9933641, PubMed:10692428, PubMed:19276089, PubMed:24936055). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:24006492, PubMed:21551074). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Synaptic cell membrane; Multi-pass membrane protein. Cell junction, focal adhesion. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3- kinase (PIK3CA) and SCAMP2. |
| Tissue Location | Mainly expressed in brain (PubMed:7759094, PubMed:9933641). Expressed in neurons of the central and peripheral nervous system (PubMed:21551074, PubMed:9933641). Expressed also in testis, spleen, and skeletal muscle (PubMed:7759094) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC9A5 is involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).
References
Diering, G.H., et al. J. Biol. Chem. 284(20):13892-13903(2009)Onishi, I., et al. Cell. Signal. 19(1):194-203(2007)Szabo, E.Z., et al. Proc. Natl. Acad. Sci. U.S.A. 102(8):2790-2795(2005)Lin, W.M., et al. Sheng Li Xue Bao 55(1):79-82(2003)Inoue, H., et al. Biol. Pharm. Bull. 26(2):148-155(2003)
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