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GGT7 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UJ14 |
|---|---|
| Clone Names | 100405213 |
| Gene ID | 2686 |
|---|---|
| Other Names | Gamma-glutamyltransferase 7, GGT 7, Gamma-glutamyltransferase-like 3, Gamma-glutamyltransferase-like 5, Gamma-glutamyltranspeptidase 7, Glutathione hydrolase 7, Gamma-glutamyltransferase 7 heavy chain, Gamma-glutamyltransferase 7 light chain, GGT7, GGTL3, GGTL5 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13155a was selected from the N-term region of GGT7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GGT7 (HGNC:4259) |
|---|---|
| Synonyms | GGTL3, GGTL5 |
| Function | Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:P19440}; Single- pass type II membrane protein {ECO:0000250|UniProtKB:P07314} |
| Tissue Location | Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a gene family that encodesenzymes involved in both the metabolism of glutathione and in thetranspeptidation of amino acids. Changes in the activity ofgamma-glutamyltransferase may signal preneoplastic or toxicconditions in the liver or kidney. The protein encoded by this geneconsists of a heavy and a light chain, and it can interact withCT120, a plasma membrane-associated protein that is possiblyinvolved in lung carcinogenesis.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)He, X., et al. Biochem. Biophys. Res. Commun. 297(3):528-536(2002)Figlewicz, D.A., et al. Genomics 17(2):299-305(1993)
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