|Other Names||Gamma-glutamyltransferase 7, GGT 7, Gamma-glutamyltransferase-like 3, Gamma-glutamyltransferase-like 5, Gamma-glutamyltranspeptidase 7, Glutathione hydrolase 7, Gamma-glutamyltransferase 7 heavy chain, Gamma-glutamyltransferase 7 light chain, GGT7, GGTL3, GGTL5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13155a was selected from the N-term region of GGT7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves glutathione conjugates.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of a gene family that encodesenzymes involved in both the metabolism of glutathione and in thetranspeptidation of amino acids. Changes in the activity ofgamma-glutamyltransferase may signal preneoplastic or toxicconditions in the liver or kidney. The protein encoded by this geneconsists of a heavy and a light chain, and it can interact withCT120, a plasma membrane-associated protein that is possiblyinvolved in lung carcinogenesis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Heisterkamp, N., et al. Hum. Genet. 123(4):321-332(2008)He, X., et al. Biochem. Biophys. Res. Commun. 297(3):528-536(2002)Figlewicz, D.A., et al. Genomics 17(2):299-305(1993)
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