|Other Names||DnaJ homolog subfamily C member 15, Cell growth-inhibiting gene 22 protein, Methylation-controlled J protein, MCJ, DNAJC15, DNAJD1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13156c was selected from the Center region of DNAJC15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
|Tissue Location||Expressed at highest levels in heart, followed by liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
DNAJC15 is absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Witham, J., et al. Int. J. Cancer 122(11):2641-2645(2008)Hatle, K.M., et al. Mol. Cell. Biol. 27(8):2952-2966(2007)Lindsey, J.C., et al. Int. J. Cancer 118(2):346-352(2006)Strathdee, G., et al. Carcinogenesis 25(5):693-701(2004)
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