|Other Names||Calpain-8, New calpain 2, nCL-2, Stomach-specific M-type calpain, CAPN8, NCL2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13161c was selected from the Center region of CAPN8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus|
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Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Hata, S., et al. J. Biol. Chem. 282(38):27847-27856(2007)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Hata, S., et al. J. Mol. Evol. 53(3):191-203(2001)Huang, Y., et al. Trends Mol Med 7(8):355-362(2001)Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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