|Other Names||Transmembrane protein 257, TMEM257, CXorf1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13165b was selected from the C-term region of CX001. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Brain. In the hippocampus it is mainly localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammon's horn EMBL; Y10607; CAA71614.1; -; Genomic_DNA EMBL; Y08902; CAA70110.1; -; mRNA EMBL; AL109653; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC113600; AAI13601.1; -; mRNA EMBL; BC113604; AAI13605.1; -; mRNA CCDS; CCDS14681.1; - RefSeq; NP_004700.1; NM_004709.2 UniGene; Hs.106688; - ProteinModelPortal; O96002; - iPTMnet; O96002; - PhosphoSitePlus; O96002; - BioMuta; TMEM257; - PaxDb; O96002; - PRIDE; O96002; - DNASU; 9142; - Ensembl; ENST00000408967; ENSP00000386149; ENSG00000221870 GeneID; 9142; - KEGG; hsa:9142; - UCSC; uc004fch.4; human CTD; 9142; - GeneCards; TMEM257; - H-InvDB; HIX0056114; - HGNC; HGNC:2562; TMEM257 HPA; HPA028857; - MIM; 300565; gene neXtProt; NX_O96002; - OpenTargets; ENSG00000221870; - PharmGKB; PA27059; - eggNOG; ENOG410KCJN; Eukaryota eggNOG; ENOG4110NW9; LUCA GeneTree; ENSGT00510000055407; - HOGENOM; HOG000112096; - InParanoid; O96002; - OMA; TIFYFRI; - OrthoDB; EOG091G0WPJ; - PhylomeDB; O96002; - BioCyc; ZFISH:G66-31656-MONOMER; - GenomeRNAi; 9142; - PRO; PR:O96002; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000221870; - CleanEx; HS_CXorf1; - Genevisible; O96002; HS GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW 2: Evidence at transcript level; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 111 Transmembrane protein 257 /FTId=PRO_0000079729 TRANSMEM 23 43 Helical. TRANSMEM 58 78 Helical. VARIANT 36 36 S -> A (in dbSNP:rs3752359) /FTId=VAR_033766 SEQUENCE 111 AA; 13452 MW; 5EFA883C1329A522 CRC64; MYSRLFYLKS SYIIYFEPLF SNAIINILSF INSLASPLTI FCFALSAQAL STIFYFRIFI FIFHSWILLF HFYFTCSFKT YEHQHSKMVP AYRMQSPRAL PRTYLYVWPY K|
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Provided below are standard protocols that you may find useful for product applications.
This intronless gene is expressed in the hippocampus andmaps close to a candidate region for several X-linked mentalretardation (XLMR) syndromes. It is conserved in primates, cow, andhorse, but not found in mouse and rat. The exact function of thisgene is not known, but on the basis of its physical location andexpression pattern, it is proposed to have an important function inthe brain.
Ross, M.T., et al. Nature 434(7031):325-337(2005)Redolfi, E., et al. DNA Cell Biol. 17(12):1009-1016(1998)
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