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TM55B Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86T03 |
|---|---|
| Clone Names | 91119278 |
| Gene ID | 90809 |
|---|---|
| Other Names | Type 1 phosphatidylinositol 4, 5-bisphosphate 4-phosphatase, Type 1 PtdIns-4, 5-P2 4-Ptase, PtdIns-4, 5-P2 4-Ptase I, Transmembrane protein 55B, TMEM55B, C14orf9 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13171b was selected from the C-term region of TM55B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIP4P1 (HGNC:19299) |
|---|---|
| Function | Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid- dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). |
| Cellular Location | Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TMEM55B catalyzes the degradation of phosphatidylinositol4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate(Ungewickell et al., 2005 [PubMed 16365287]).
References
Zou, J., et al. Proc. Natl. Acad. Sci. U.S.A. 104(43):16834-16839(2007)Ungewickell, A., et al. Proc. Natl. Acad. Sci. U.S.A. 102(52):18854-18859(2005)
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