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ME11A Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BV86
Clone Names 91208329
Peptide ID 91208329
Additional Information
Gene ID 28989
Other Names N-terminal Xaa-Pro-Lys N-methyltransferase 1, Alpha N-terminal protein methyltransferase 1A, Methyltransferase-like protein 11A, N-terminal RCC1 methyltransferase, X-Pro-Lys N-terminal protein methyltransferase 1A, NTM1A, N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed, NTMT1, C9orf32, METTL11A, NRMT, NRMT1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13172a was selected from the N-term region of ME11A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTMT1
Synonyms C9orf32, METTL11A, NRMT, NRMT1
Function Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Cellular Location Nucleus. Note=Predominantly nuclear
Research Areas
Citations (0)

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The METTL11A gene encodes an N-terminal methyltransferasefor the RAN (MIM 601179) guanine nucleotide exchange factorregulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11Aenzyme alpha-N-methylates other protein targets such as SET (MIM600960) and RB (MIM 180200).


Tooley, C.E., et al. Nature 466(7310):1125-1128(2010)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)

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$ 80.00
Cat# BP13172a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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