|Other Names||G antigen 2B/2C, GAGE-2B, GAGE-2C, Cancer/testis antigen 42, CT42, G antigen 2C, GAGE2B, GAGE2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13173a was selected from the N-term region of GAGE2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes.|
|Tissue Location||Expressed in a variety of tumor tissues but not in normal tissues, except testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to a family of genes that are expressedin a variety of tumors but not in normal tissues, except for thetestis. The sequences of the family members are highly related butdiffer by scattered nucleotide substitutions. The antigenic peptideYRPRPRRY, which is also encoded by several other family members, isrecognized by autologous cytolytic T lymphocytes. [provided byRefSeq].
Sun, F., et al. Mol. Cancer Ther. 8(12):3191-3202(2009)Gjerstorff, M.F., et al. Tissue Antigens 71(3):187-192(2008)Ross, M.T., et al. Nature 434(7031):325-337(2005)De Backer, O., et al. Cancer Res. 59(13):3157-3165(1999)Scarcella, D.L., et al. Clin. Cancer Res. 5(2):335-341(1999)
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