|Other Names||Angiomotin-like protein 1, AMOTL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13179b was selected from the C-term region of AMOTL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.|
|Cellular Location||Cell junction, tight junction.|
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The protein encoded by this gene is a peripheral membraneprotein that is a component of tight junctions or TJs. TJs form anapical junctional structure and act to control paracellularpermeability and maintain cell polarity. This protein is related toangiomotin, an angiostatin binding protein that regulatesendothelial cell migration and capillary formation. [provided byRefSeq].
Pei, Z., et al. Virology 397(1):155-166(2010)Gagne, V., et al. Cell Motil. Cytoskeleton 66(9):754-768(2009)Zheng, Y., et al. Circ. Res. 105(3):260-270(2009)Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1369-1378 (2008) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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