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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Puma BH3 Domain Antibody Blocking Peptide   

Puma BH3 Domain Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BXH1
Clone Names 2041511
Peptide ID 2041511
Additional Information
Gene ID 27113
Other Names Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis, BBC3, PUMA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1317a was selected from the region of human Puma BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BBC3
Synonyms PUMA
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
Cellular Location Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.


Liu, F.T., et al., Biochem. Biophys. Res. Commun. 310(3):956-962 (2003).Hoque, M.O., et al., Cancer Lett. 199(1):75-81 (2003).Yu, J., et al., Proc. Natl. Acad. Sci. U.S.A. 100(4):1931-1936 (2003).Han, J., et al., Proc. Natl. Acad. Sci. U.S.A. 98(20):11318-11323 (2001).Nakano, K., et al., Mol. Cell 7(3):683-694 (2001).

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$ 80.00
Cat# BP1317a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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