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KDELR3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43731 |
|---|---|
| Clone Names | 100406021 |
| Gene ID | 11015 |
|---|---|
| Other Names | ER lumen protein-retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3, KDEL receptor 3, KDELR3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13180a was selected from the N-term region of KDELR3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KDELR3 |
|---|---|
| Synonyms | ERD23 {ECO:0000303|PubMed:18086916} |
| Function | Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L |
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Provided below are standard protocols that you may find useful for product applications.
Background
Retention of resident soluble proteins in the lumen ofthe endoplasmic reticulum (ER) is achieved in both yeast and animalcells by their continual retrieval from the cis-Golgi, or apre-Golgi compartment. Sorting of these proteins is dependent on aC-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) inanimal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. Thisprocess is mediated by a receptor that recognizes, and binds thetetrapeptide-containing protein, and returns it to the ER. Inyeast, the sorting receptor encoded by a single gene, ERD2, is aseven-transmembrane protein. Unlike yeast, several human homologsof the ERD2 gene, constituting the KDEL receptor gene family, havebeen described. KDELR3 was the third member of the family to beidentified, and it encodes a protein highly homologous to KDELR1and KDELR2 proteins. Two transcript variants of KDELR3 that ariseby alternative splicing, and encode different isoforms of KDELR3receptor, have been described.
References
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Collins, J.E., et al. Genome Res. 13(1):27-36(2003)Dunham, I., et al. Nature 402(6761):489-495(1999)Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)
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