|Other Names||Heme-binding protein 2, Placental protein 23, PP23, Protein SOUL, HEBP2, C6orf34, SOUL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13181a was selected from the N-term region of HEBP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Mainly localized to the cytoplasm with a much lower abundance in the mitochondrion|
|Tissue Location||Detected in placenta.|
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Provided below are standard protocols that you may find useful for product applications.
HEBP2 can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
Szigeti, A., et al. J. Biol. Chem. 285(3):2140-2151(2010)Freire, F., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 7), 723-726 (2009) :Szigeti, A., et al. FEBS Lett. 580(27):6447-6454(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Liu, L., et al. Genomics 79(1):124-136(2002)
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