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CXorf15 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NUQ3
Clone Names 100406085
Additional Information
Gene ID 55787
Other Names Gamma-taxilin, Environmental lipopolysaccharide-responding gene protein, Factor inhibiting ATF4-mediated transcription, FIAT, Lipopolysaccharide-specific response protein 5, TXLNG, CXorf15, ELRG, LSR5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13184b was selected from the C-term region of CXorf15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXLNG
Synonyms CXorf15, ELRG, LSR5
Function May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.
Cellular Location Nucleus membrane. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BHN1}
Tissue Location Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.
Research Areas
Citations (0)
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Background

This gene encodes a member of the taxilin family. Theencoded protein binds to the C-terminal coiled-coil region ofsyntaxin family members 1A, 3A and 4A, and may play a role inintracellular vesicle trafficking. This gene is up-regulated bylipopolysaccharide and the gene product may be involved in cellcycle regulation. The related mouse protein was also shown toinhibit activating transcription factor 4-mediated transcriptionand thus regulate bone mass accrual. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.

References

Du, K., et al. Toxicology 243(3):303-310(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Yu, V.W., et al. Ann. N. Y. Acad. Sci. 1068, 131-142 (2006) :Yu, V.W., et al. J. Cell Biol. 169(4):591-601(2005)

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$ 277.78
Cat# BP13184b
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