CXorf15 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NUQ3 |
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Clone Names | 100406085 |
Gene ID | 55787 |
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Other Names | Gamma-taxilin, Environmental lipopolysaccharide-responding gene protein, Factor inhibiting ATF4-mediated transcription, FIAT, Lipopolysaccharide-specific response protein 5, TXLNG, CXorf15, ELRG, LSR5 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13184b was selected from the C-term region of CXorf15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TXLNG |
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Synonyms | CXorf15, ELRG, LSR5 |
Function | May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression. |
Cellular Location | Nucleus membrane. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BHN1} |
Tissue Location | Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the taxilin family. Theencoded protein binds to the C-terminal coiled-coil region ofsyntaxin family members 1A, 3A and 4A, and may play a role inintracellular vesicle trafficking. This gene is up-regulated bylipopolysaccharide and the gene product may be involved in cellcycle regulation. The related mouse protein was also shown toinhibit activating transcription factor 4-mediated transcriptionand thus regulate bone mass accrual. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
References
Du, K., et al. Toxicology 243(3):303-310(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Yu, V.W., et al. Ann. N. Y. Acad. Sci. 1068, 131-142 (2006) :Yu, V.W., et al. J. Cell Biol. 169(4):591-601(2005)
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