|Other Names||Calcium-activated chloride channel regulator 4, 34--, Calcium-activated chloride channel family member 4, hCLCA4, Calcium-activated chloride channel protein 2, CaCC-2, hCaCC-2, Calcium-activated chloride channel regulator 4, 110 kDa form, Calcium-activated chloride channel regulator 4, 30 kDa form, CLCA4, CaCC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13186a was selected from the N-term region of CLCA4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in mediating calcium-activated chloride conductance.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus|
|Tissue Location||Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the calciumsensitive chloride conductance protein family. To date, all membersof this gene family map to the same site on chromosome 1p31-p22 andshare high degrees of homology in size, sequence and predictedstructure, but differ significantly in their tissue distributions.Alternative splicing results in multiple transcript variants, onlyone of which is thought to be protein coding.
Ritzka, M., et al. Hum. Genet. 115(6):483-491(2004)Pauli, B.U., et al. Clin. Exp. Pharmacol. Physiol. 27(11):901-905(2000)Agnel, M., et al. FEBS Lett. 455(3):295-301(1999)
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