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MRAP2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96G30 |
|---|---|
| Clone Names | 100406113 |
| Gene ID | 112609 |
|---|---|
| Other Names | Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13187c was selected from the Center region of MRAP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MRAP2 |
|---|---|
| Synonyms | C6orf117 |
| Function | Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand- sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. |
| Cellular Location | Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. |
| Tissue Location | Expressed in the adrenal gland and brain. Not expressed in other tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Sebag, J.A., et al. Sci Signal 3 (116), RA28 (2010) :Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)Sebag, J.A., et al. J. Biol. Chem. 284(1):610-618(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Metherell, L.A., et al. Nat. Genet. 37(2):166-170(2005)
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