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MRAP2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96G30
Clone Names 100406113
Peptide ID 100406113
Additional Information
Gene ID 112609
Other Names Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13187c was selected from the Center region of MRAP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRAP2
Synonyms C6orf117
Function Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Cellular Location Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context
Tissue Location Expressed in the adrenal gland and brain. Not expressed in other tissues.
Research Areas
Citations (0)

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The specific function of this protein remains unknown.


Sebag, J.A., et al. Sci Signal 3 (116), RA28 (2010) :Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)Sebag, J.A., et al. J. Biol. Chem. 284(1):610-618(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Metherell, L.A., et al. Nat. Genet. 37(2):166-170(2005)

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$ 80.00
Cat# BP13187c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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