GAL3ST3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96A11 |
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Clone Names | 100406126 |
Gene ID | 89792 |
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Other Names | Galactose-3-O-sulfotransferase 3, Gal3ST-3, 282-, Beta-galactose-3-O-sulfotransferase 3, Gal3ST3, Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3, GAL3ST3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13192c was selected from the Center region of GAL3ST3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GAL3ST3 |
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Function | Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc. |
Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein |
Tissue Location | Highly expressed in thyroid, brain, kidney, heart and spinal cord. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of thegalactose-3-O-sulfotransferase protein family. The product of thisgene catalyzes sulfonation by transferring a sulfate group to the3' position of galactose in N-acetyllactosamine in both type 2(Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branchedO-glycans, but not on type 1 or core-1-branched structures. Thisgene, which has also been referred to as GAL3ST2, is different fromthe GAL3ST2 gene located on chromosome 2 that encodes a relatedenzyme with distinct tissue distribution and substratespecificities, compared to galactose-3-O-sulfotransferase 3.
References
Chandrasekaran, E.V., et al. J. Biol. Chem. 279(11):10032-10041(2004)El-Fasakhany, F.M., et al. J. Biol. Chem. 276(29):26988-26994(2001)Seko, A., et al. J. Biol. Chem. 276(28):25697-25704(2001)Suzuki, A., et al. J. Biol. Chem. 276(26):24388-24395(2001)Chandrasekaran, E.V., et al. Glycoconj. J. 16(9):523-536(1999)
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