|Other Names||Glycine receptor subunit alpha-3, GLRA3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13195b was selected from the C-term region of GLRA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely distributed throughout the central nervous system|
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Provided below are standard protocols that you may find useful for product applications.
The GLRA3 gene encodes the alpha-3 subunit of the neuronalglycine receptor, a ligand-gated chloride channel composed ofligand-binding alpha and structural beta polypeptides (Kingsmore etal., 1994 [PubMed 7894176]).
Melzer, N., et al. J. Biol. Chem. 285(6):3730-3739(2010)Breitinger, H.G., et al. J. Biol. Chem. 284(42):28624-28633(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Breitinger, H.G., et al. J. Neurochem. 83(1):30-36(2002)Sobetzko, D., et al. Am. J. Med. Genet. 105(6):534-538(2001)
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