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GLRA3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75311
Clone Names 100406138
Peptide ID 100406138
Additional Information
Gene ID 8001
Other Names Glycine receptor subunit alpha-3, GLRA3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13195b was selected from the C-term region of GLRA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLRA3
Function Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).
Cellular Location Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P24524}; Multi-pass membrane protein. Perikaryon {ECO:0000250|UniProtKB:P24524} Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Cell junction, synapse {ECO:0000250|UniProtKB:P24524}. Cell membrane; Multi- pass membrane protein Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes {ECO:0000250|UniProtKB:P24524}
Tissue Location Widely distributed throughout the central nervous system.
Research Areas
Citations (0)

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The GLRA3 gene encodes the alpha-3 subunit of the neuronalglycine receptor, a ligand-gated chloride channel composed ofligand-binding alpha and structural beta polypeptides (Kingsmore etal., 1994 [PubMed 7894176]).


Melzer, N., et al. J. Biol. Chem. 285(6):3730-3739(2010)Breitinger, H.G., et al. J. Biol. Chem. 284(42):28624-28633(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Breitinger, H.G., et al. J. Neurochem. 83(1):30-36(2002)Sobetzko, D., et al. Am. J. Med. Genet. 105(6):534-538(2001)

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$ 80.00
Cat# BP13195b
Availability: In Stock
Bulk Size
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