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ABCC12 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96J65 |
|---|---|
| Clone Names | 100406141 |
| Gene ID | 94160 |
|---|---|
| Other Names | Multidrug resistance-associated protein 9, ATP-binding cassette sub-family C member 12, ABCC12, MRP9 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13196c was selected from the Center region of ABCC12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ABCC12 |
|---|---|
| Synonyms | MRP9 |
| Function | Probable transporter, its substrate specificity is unknown. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} |
| Tissue Location | Expressed in testis (at protein level). Widely expressed at low level (PubMed:11483364, PubMed:11688999, PubMed:12011458, PubMed:17472575). Isoform 5 is specifically expressed in brain, testis and breast cancer cells (PubMed:11483364, PubMed:11688999, PubMed:12011458). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the superfamily of ATP-bindingcassette (ABC) transporters and the encoded protein contains twoATP-binding domains and 12 transmembrane regions. ABC proteinstransport various molecules across extra- and intracellularmembranes. ABC genes are divided into seven distinct subfamilies:ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is amember of the MRP subfamily which is involved in multi-drugresistance. This gene and another subfamily member are arrangedhead-to-tail on chromosome 16q12.1. Increased expression of thisgene is associated with breast cancer.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Haimeur, A., et al. Curr. Drug Metab. 5(1):21-53(2004)Bera, T.K., et al. Proc. Natl. Acad. Sci. U.S.A. 99(10):6997-7002(2002)Yabuuchi, H., et al. Biochem. Biophys. Res. Commun. 288(4):933-939(2001)Tammur, J., et al. Gene 273(1):89-96(2001)
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