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Bik BH3 Domain Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13323
Clone Names 2101107
Peptide ID 2101107
Additional Information
Gene ID 638
Other Names Bcl-2-interacting killer, Apoptosis inducer NBK, BIP1, BP4, BIK, NBK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1319a was selected from the region of human Bik BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BIK
Synonyms NBK
Function Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Cellular Location Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes
Research Areas
Citations (0)

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The Bik protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.


Arena, V., et al., Genes Chromosomes Cancer 38(1):91-96 (2003).Gillissen, B., et al., EMBO J. 22(14):3580-3590 (2003).Germain, M., et al., J. Biol. Chem. 277(20):18053-18060 (2002).Zou, Y., et al., Cancer Res. 62(1):8-12 (2002).Castells, A., et al., Gastroenterology 117(4):831-837 (1999).

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$ 80.00
Cat# BP1319a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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