DNTTIP1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H147 |
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Clone Names | 100406203 |
Gene ID | 116092 |
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Other Names | Deoxynucleotidyltransferase terminal-interacting protein 1, Terminal deoxynucleotidyltransferase-interacting factor 1, TdIF1, TdT-interacting factor 1, DNTTIP1, C20orf167, TDIF1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13202c was selected from the Center region of DNTTIP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DNTTIP1 |
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Synonyms | C20orf167, TDIF1 |
Function | Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. |
Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNTTIP1 binds DNA and enhances the activity of terminaldeoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNApolymerase that catalyzes the polymerization of DNA in the absenceof a DNA template (Yamashita et al., 2001 [PubMed11473582]).
References
Kubota, T., et al. Genes Cells 12(8):941-959(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Tomarev, S.I., et al. Invest. Ophthalmol. Vis. Sci. 44(6):2588-2596(2003)
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