|Other Names||Deoxynucleotidyltransferase terminal-interacting protein 1, Terminal deoxynucleotidyltransferase-interacting factor 1, TdIF1, TdT-interacting factor 1, DNTTIP1, C20orf167, TDIF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13202c was selected from the Center region of DNTTIP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'- GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.|
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Provided below are standard protocols that you may find useful for product applications.
DNTTIP1 binds DNA and enhances the activity of terminaldeoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNApolymerase that catalyzes the polymerization of DNA in the absenceof a DNA template (Yamashita et al., 2001 [PubMed11473582]).
Kubota, T., et al. Genes Cells 12(8):941-959(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Tomarev, S.I., et al. Invest. Ophthalmol. Vis. Sci. 44(6):2588-2596(2003)
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