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XPNPEP3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NQH7 |
|---|---|
| Clone Names | 100406206 |
| Gene ID | 63929 |
|---|---|
| Other Names | Probable Xaa-Pro aminopeptidase 3, X-Pro aminopeptidase 3, Aminopeptidase P3, APP3, XPNPEP3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13203b was selected from the C-term region of XPNPEP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | XPNPEP3 |
|---|---|
| Function | Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). |
| Cellular Location | [Isoform 1]: Mitochondrion. Cytoplasm. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation |
| Tissue Location | Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
XPNPEP3 belongs to a family of X-pro-aminopeptidases (EC3.4.11.9) that utilize a metal cofactor and remove the N-terminalamino acid from peptides with a proline residue in the penultimateposition (summary by Ersahin et al., 2005 [PubMed15708373]).
References
O'Toole, J.F., et al. J. Clin. Invest. 120(3):791-802(2010)Ersahin, C., et al. Arch. Biochem. Biophys. 435(2):303-310(2005)Bouwmeester, T., et al. Nat. Cell Biol. 6(2):97-105(2004)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Dunham, I., et al. Nature 402(6761):489-495(1999)
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