RPL34 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49207 |
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Clone Names | 90909188 |
Gene ID | 6164 |
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Other Names | 60S ribosomal protein L34, RPL34 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13207c was selected from the Center region of RPL34. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RPL34 |
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Function | Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680, PubMed:32669547). |
Cellular Location | Cytoplasm, cytosol. Cytoplasm Endoplasmic reticulum {ECO:0000250|UniProtKB:Q29223}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity) {ECO:0000250|UniProtKB:Q29223, ECO:0000269|PubMed:25957688} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L34E family of ribosomal proteins. It is located in thecytoplasm. This gene originally was thought to be located at 17q21,but it has been mapped to 4q. Transcript variants derived fromalternative splicing, alternative transcription initiation sites,and/or alternative polyadenylation exist; these variants encode thesame protein. As is typical for genes encoding ribosomal proteins,there are multiple processed pseudogenes of this gene dispersedthrough the genome.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Andersen, J.S., et al. Nature 433(7021):77-83(2005)Kapp, L.D., et al. Annu. Rev. Biochem. 73, 657-704 (2004) :Mazumder, B., et al. Cell 115(2):187-198(2003)
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