|Other Names||AFG3-like protein 2, 3424-, Paraplegin-like protein, AFG3L2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13219a was selected from the N-term region of AFG3L2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU.|
|Cellular Location||Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in the cerebellar Purkinje cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein localized in mitochondria andclosely related to paraplegin. The paraplegin gene is responsiblefor an autosomal recessive form of hereditary spastic paraplegia.This gene is a candidate gene for other hereditary spasticparaplegias or neurodegenerative disorders.
Edener, U., et al. Eur. J. Hum. Genet. 18(8):965-968(2010)Di Bella, D., et al. Nat. Genet. 42(4):313-321(2010)Augustin, S., et al. Mol. Cell 35(5):574-585(2009)Mariotti, C., et al. Cerebellum 7(2):184-188(2008)Cagnoli, C., et al. Brain 129 (PT 1), 235-242 (2006) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.