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HOOK3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86VS8
Clone Names 100324260
Peptide ID 100324260
Additional Information
Gene ID 84376
Other Names Protein Hook homolog 3, h-hook3, hHK3, HOOK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13225c was selected from the Center region of HOOK3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HOOK3
Function Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.
Cellular Location Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase
Research Areas
Citations (0)

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Hook proteins are cytosolic coiled-coil proteins thatcontain conserved N-terminal domains, which attach to microtubules,and more divergent C-terminal domains, which mediate binding toorganelles. The Drosophila Hook protein is a component of theendocytic compartment.


Ge, X., et al. Neuron 65(2):191-203(2010)Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)Ciampi, R., et al. Endocr. Relat. Cancer 14(2):445-452(2007)Sano, H., et al. J. Biol. Chem. 282(11):7973-7981(2007)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)

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$ 80.00
Cat# BP13225c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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