|Other Names||Sodium/hydrogen exchanger 6, Na(+)/H(+) exchanger 6, NHE-6, Solute carrier family 9 member 6, SLC9A6, KIAA0267, NHE6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13226b was selected from the C-term region of SLC9A6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Note=Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane|
|Tissue Location||Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a sodium-hydrogen exchanger that isamember of the solute carrier family 9. The encoded proteinlocalizes to early and recycling endosomes and may be involved inregulating endosomal pH and volume. Defects in this gene areassociated with X-linked syndromic mental retardation, Christiansontype. Alternate splicing results in multiple transcript variants.
Garbern, J.Y., et al. Brain 133 (PT 5), 1391-1402 (2010) :Ohgaki, R., et al. Mol. Biol. Cell 21(7):1293-1304(2010)Fukura, N., et al. J. Membr. Biol. 234(3):149-158(2010)Fichou, Y., et al. Eur. J. Hum. Genet. 17(11):1378-1380(2009)Roxrud, I., et al. Exp. Cell Res. 315(17):3014-3027(2009)
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