|Other Names||Sphingosine-1-phosphate phosphatase 1, SPPase1, Spp1, hSPP1, hSPPase1, 313-, Sphingosine-1-phosphatase 1, SGPP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13228a was selected from the N-term region of SGPP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous, with the strongest level in placenta and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipidmetabolite that regulates diverse biologic processes. SGPP1catalyzes the degradation of S1P via salvage and recycling ofsphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied byOMIM].
Hicks, A.A., et al. PLoS Genet. 5 (10), E1000672 (2009) :Le Stunff, H., et al. J. Biol. Chem. 282(47):34372-34380(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Giussani, P., et al. Mol. Cell. Biol. 26(13):5055-5069(2006)
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