|Other Names||Sphingosine-1-phosphate phosphatase 1, SPPase1, Spp1, hSPP1, hSPPase1, 313-, Sphingosine-1-phosphatase 1, SGPP1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13228a was selected from the N-term region of SGPP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous, with the strongest level in placenta and kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipidmetabolite that regulates diverse biologic processes. SGPP1catalyzes the degradation of S1P via salvage and recycling ofsphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied byOMIM].
Hicks, A.A., et al. PLoS Genet. 5 (10), E1000672 (2009) :Le Stunff, H., et al. J. Biol. Chem. 282(47):34372-34380(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Giussani, P., et al. Mol. Cell. Biol. 26(13):5055-5069(2006)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.