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PGAP3 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96FM1
Clone Names 100405118
Peptide ID 100405118
Additional Information
Gene ID 93210
Other Names Post-GPI attachment to proteins factor 3, COS16 homolog, hCOS16, Gene coamplified with ERBB2 protein, PER1-like domain-containing protein 1, PGAP3, CAB2, PERLD1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13237c was selected from the Center region of PGAP3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGAP3
Synonyms CAB2, PERLD1
Function Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable).
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly localizes to Golgi apparatus.
Tissue Location Ubiquitously expressed, with highest levels in thyroid and placenta.
Research Areas
Citations (0)

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Background

PGAP3 is involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable).

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)Maeda, Y., et al. Mol. Biol. Cell 18(4):1497-1506(2007)Benusiglio, P.R., et al. Br. J. Cancer 95(12):1689-1695(2006)

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$ 80.00
Cat# BP13237c
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