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SC65 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92791
Clone Names 100406057
Peptide ID 100406057
Additional Information
Gene ID 10609
Other Names Synaptonemal complex protein SC65, Leprecan-like protein 4, Nucleolar autoantigen No55, LEPREL4, NOL55, SC65
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13238b was selected from the C-term region of SC65. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name P3H4 (HGNC:16946)
Function Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.
Cellular Location Endoplasmic reticulum
Tissue Location Detected in fibroblasts (at protein level) (PubMed:23959653). Detected in spleen, prostate, testis, ovary, colon, pancreas, kidney, placenta and heart (PubMed:10952778)
Research Areas
Citations (0)

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Background

This nucleolar protein was first characterized because itwas an autoantigen in cases on interstitial cystitis. The protein,with a predicted molecular weight of 50 kDa, appears to belocalized in the particulate compartment of the interphasenucleolus, with a distribution distinct from that of nucleolarprotein B23. During mitosis it is associated with chromosomes.

References

Foster, L.J., et al. J. Proteome Res. 5(1):64-75(2006)Fossa, A., et al. Br. J. Cancer 83(6):743-749(2000)Ochs, R.L., et al. Mol. Biol. Cell 7(7):1015-1024(1996)

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$ 80.00
Cat# BP13238b
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