|Other Names||Synaptonemal complex protein SC65, Leprecan-like protein 4, Nucleolar autoantigen No55, LEPREL4, NOL55, SC65|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13238b was selected from the C-term region of SC65. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.|
|Cellular Location||Endoplasmic reticulum|
|Tissue Location||Detected in fibroblasts (at protein level) (PubMed:23959653). Detected in spleen, prostate, testis, ovary, colon, pancreas, kidney, placenta and heart (PubMed:10952778)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This nucleolar protein was first characterized because itwas an autoantigen in cases on interstitial cystitis. The protein,with a predicted molecular weight of 50 kDa, appears to belocalized in the particulate compartment of the interphasenucleolus, with a distribution distinct from that of nucleolarprotein B23. During mitosis it is associated with chromosomes.
Foster, L.J., et al. J. Proteome Res. 5(1):64-75(2006)Fossa, A., et al. Br. J. Cancer 83(6):743-749(2000)Ochs, R.L., et al. Mol. Biol. Cell 7(7):1015-1024(1996)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.