|Other Names||Dachshund homolog 2, Dach2, DACH2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13241a was selected from the N-term region of DACH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.|
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This gene is one of two genes which encode a proteinsimilar to the Drosophila protein dachshund, a transcription factorinvolved in cell fate determination in the eye, limb and genitaldisc of the fly. The encoded protein contains two characteristicdachshund domains: an N-terminal domain responsible for DNA bindingand a C-terminal domain responsible for protein-proteininteractions. This gene is located on the X chromosome and issubject to inactivation by DNA methylation. The encoded protein maybe involved in regulation of organogenesis and myogenesis, and mayplay a role in premature ovarian failure. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Styrkarsdottir, U., et al. Nat. Genet. 41(1):15-17(2009)Poulin, F., et al. Genomics 85(6):774-781(2005)Bione, S., et al. Hum. Reprod. 19(12):2759-2766(2004)
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