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CCDC134 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H6E4
Clone Names 100406275
Peptide ID 100406275
Additional Information
Gene ID 79879
Other Names Coiled-coil domain-containing protein 134, CCDC134
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13242b was selected from the C-term region of CCDC134. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCDC134
Function In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
Cellular Location Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376)
Tissue Location Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8(+) T cells, and also expressed at lower levels in CD4(+) T cells (PubMed:25125657).
Research Areas
Citations (0)

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Background

The specific function of this protein remains unknown.

References

Huang, J., et al. Cell. Mol. Life Sci. 65(2):338-349(2008)Lim, J., et al. Cell 125(4):801-814(2006)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Dunham, I., et al. Nature 402(6761):489-495(1999)

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$ 80.00
Cat# BP13242b
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