|Other Names||Sodium/hydrogen exchanger 7, Na(+)/H(+) exchanger 7, NHE-7, Solute carrier family 9 member 7, SLC9A7, NHE7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13243b was selected from the C-term region of SLC9A7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Organelles of the secretory and endocytic pathways aredistinguished by their luminal acidity, which is generated by theactivity of an electrogenic vacuolar-type hydrogen ATPase.Progressive acidification of vesicles in the endocytic pathway isessential for the redistribution and degradation of internalizedmembrane proteins, such as ligand receptor complexes andfluid-phase solutes. This gene is expressed predominantly in thetrans-Golgi network, and mediates the influx of sodium or potassiumin exchange for hydrogen. It may thus play an important role inmaintaining cation homeostasis and function of the trans-Golginetwork. This gene is part of a gene cluster on chromosome Xp11.23.
Fukura, N., et al. J. Membr. Biol. 234(3):149-158(2010)Kagami, T., et al. Mol. Membr. Biol. 25(5):436-447(2008)Lin, P.J., et al. J. Cell. Sci. 118 (PT 9), 1885-1897 (2005) :Ross, M.T., et al. Nature 434(7031):325-337(2005)Thiselton, D.L., et al. Genomics 79(4):560-572(2002)
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