|Other Names||Cadherin-22, Pituitary and brain cadherin, PB-cadherin, CDH22, C20orf25|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13244c was selected from the Center region of CDH22. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cadherin superfamily. Thegene product is composed of five cadherin repeat domains and acytoplasmic tail similar to the highly conserved cytoplasmic regionof classical cadherins. Expressed predominantly in the brain, thisputative calcium-dependent cell adhesion protein may play animportant role in morphogenesis and tissue formation in neural andnon-neural cells during development and maintenance of the brainand neuroendocrine organs.
Lewis, J.P., et al. Genomics (2010) In press :Liu, Y., et al. Cancer Biol. Ther. 8(14):1352-1359(2009)Zhou, J., et al. Tumour Biol. 30(3):130-140(2009)Bento, J.L., et al. Genomics 92(4):226-234(2008)Wu, J., et al. J. Endocrinol. 176(3):381-391(2003)
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