|Other Names||Tubulin beta-8 chain, TUBB8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13248a was selected from the N-term region of TUBB8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle|
|Tissue Location||Expressed at a high level in oocytes, at different stages of development.|
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Provided below are standard protocols that you may find useful for product applications.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).
van Geel, M., et al. Am. J. Hum. Genet. 70(1):269-278(2002)van Geel, M., et al. Cytogenet. Cell Genet. 88 (3-4), 316-321 (2000) :
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