|Other Names||GDNF family receptor alpha-4, GDNF receptor alpha-4, GDNFR-alpha-4, GFR-alpha-4, Persephin receptor, GFRA4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13249c was selected from the Center region of GFRA4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.|
|Cellular Location||Isoform GFRalpha4a: Cell membrane; Lipid- anchor, GPI-anchor Isoform GFRalpha4c: Secreted.|
|Tissue Location||Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the GDNFreceptor family. It is a glycosylphosphatidylinositol(GPI)-linkedcell surface receptor for persephin, and mediates activation of theRET tyrosine kinase receptor. This gene is a candidate gene forRET-associated diseases. Alternatively spliced transcript variantsencoding different isoforms have been described for this gene.
Yang, J., et al. FEBS Lett. 569 (1-3), 267-271 (2004) :Borrego, S., et al. J. Med. Genet. 40 (3), E18 (2003) :Deloukas, P., et al. Nature 414(6866):865-871(2001)Zhou, B., et al. Pediatr. Neurol. 25(2):156-161(2001)Lindahl, M., et al. J. Biol. Chem. 276(12):9344-9351(2001)
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