|Other Names||Transmembrane emp24 domain-containing protein 9, GMP25, Glycoprotein 25L2, p24 family protein alpha-2, p24alpha2, p25, TMED9, GP25L2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13250b was selected from the C-term region of TMED9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Cycles between compartments of the early secretatory pathway|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of this protein remains unknown.
Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)Renz, M., et al. J. Biol. Chem. 275(14):10429-10436(2000)Wada, I., et al. J. Biol. Chem. 266(29):19599-19610(1991)
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