|Other Names||Transcription factor AP-2-beta, AP2-beta, Activating enhancer-binding protein 2-beta, TFAP2B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13256b was selected from the C-term region of TFAP2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.|
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This gene encodes a member of the AP-2 family oftranscription factors. AP-2 proteins form homo- or hetero-dimerswith other AP-2 family members and bind specific DNA sequences.They are thought to stimulate cell proliferation and suppressterminal differentiation of specific cell types during embryonicdevelopment. Specific AP-2 family members differ in theirexpression patterns and binding affinity for different promoters.This protein functions as both a transcriptional activator andrepressor. Mutations in this gene result in autosomal dominant Charsyndrome, suggesting that this gene functions in thedifferentiation of neural crest cell derivatives. [provided byRefSeq].
Li, X., et al. Genes Chromosomes Cancer 49(9):819-830(2010)Hotta, K., et al. J. Hum. Genet. (2010) In press :Ugi, S., et al. Obesity (Silver Spring) 18(7):1277-1282(2010)Nordquist, N., et al. Brain Res. 1305 SUPPL, S20-S26 (2009) :Lindgren, C.M., et al. PLoS Genet. 5 (6), E1000508 (2009) :
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