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TRIM11 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96F44
Clone Names 100408306
Peptide ID 100408306
Additional Information
Gene ID 81559
Other Names E3 ubiquitin-protein ligase TRIM11, 632-, Protein BIA1, RING finger protein 92, Tripartite motif-containing protein 11, TRIM11, RNF92
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13284b was selected from the C-term region of TRIM11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM11
Synonyms RNF92
Function E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. This protein localizes to the nucleus andthe cytoplasm. Its function has not been identified. [provided byRefSeq].


Aurino, S., et al. Acta Myol 27, 90-97 (2008) :Hong, S.J., et al. Biochem. Biophys. Res. Commun. 368(3):650-655(2008)Uchil, P.D., et al. PLoS Pathog. 4 (2), E16 (2008) :Ishikawa, H., et al. FEBS Lett. 580(20):4784-4792(2006)Cooper, S.T., et al. BMC Genet. 6, 43 (2005) :

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$ 80.00
Cat# BP13284b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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