TRIM4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9C037 |
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Clone Names | 100408326 |
Gene ID | 89122 |
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Other Names | E3 ubiquitin-protein ligase TRIM4, 632-, RING finger protein 87, Tripartite motif-containing protein 4, TRIM4, RNF87 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13289a was selected from the N-term region of TRIM4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIM4 |
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Synonyms | RNF87 |
Function | E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to cytoplasmicbodies. Its function has not been identified. Alternatively splicedtranscript variants that encode different isoforms have beendescribed.
References
Kasyapa, C., et al. Proteomics 9(16):3979-3988(2009)Li, X., et al. Virology 360(2):419-433(2007)Thompson, E.E., et al. Pharmacogenomics J. 6(2):105-114(2006)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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