|Other Names||E3 ubiquitin-protein ligase TRIM4, 632-, RING finger protein 87, Tripartite motif-containing protein 4, TRIM4, RNF87|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13289a was selected from the N-term region of TRIM4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. The protein localizes to cytoplasmicbodies. Its function has not been identified. Alternatively splicedtranscript variants that encode different isoforms have beendescribed.
Kasyapa, C., et al. Proteomics 9(16):3979-3988(2009)Li, X., et al. Virology 360(2):419-433(2007)Thompson, E.E., et al. Pharmacogenomics J. 6(2):105-114(2006)Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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