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CASP7 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P55210
Clone Names 80410107
Peptide ID 80410107
Additional Information
Gene ID 840
Other Names Caspase-7, CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7 subunit p20, Caspase-7 subunit p11, CASP7, MCH3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1328b was selected from the Center region of human CASP7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP7
Synonyms MCH3
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
Research Areas
Citations (0)

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CASP7 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis.


Xu,H.L., Cancer Epidemiol. Biomarkers Prev. 18 (7), 2114-2122 (2009)Gibot,L., Biochem. J. 420 (3), 473-483 (2009)Kim,Y.R., Hum. Pathol. 40 (6), 868-871 (2009)

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$ 80.00
Cat# BP1328b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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