|Other Names||Tripartite motif-containing protein 54, Muscle-specific RING finger protein, MuRF, Muscle-specific RING finger protein 3, MuRF-3, MuRF3, RING finger protein 30, TRIM54, MURF, MURF3, RNF30|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13292a was selected from the N-term region of TRIM54. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||MURF, MURF3, RNF30|
|Function||May bind and stabilize microtubules during myotubes formation.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).|
|Tissue Location||Specifically expressed in heart and skeletal muscle.|
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The protein encoded by this gene contains a RING fingermotif and is highly similar to the ring finger proteins RNF28/MURF1and RNF29/MURF2. In vitro studies demonstrated that this protein,RNF28, and RNF29 form heterodimers, which may be important for theregulation of titin kinase and microtubule-dependent signalpathways in striated muscles. Alternatively spliced transcriptvariants encoding distinct isoforms have been reported. [providedby RefSeq].
Centner, T., et al. J. Mol. Biol. 306(4):717-726(2001)Spencer, J.A., et al. J. Cell Biol. 150(4):771-784(2000)
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