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FOXO3 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O43524
Clone Names 100409020
Peptide ID 100409020
Additional Information
Gene ID 2309
Other Names Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FOXO3, FKHRL1, FOXO3A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13306a was selected from the N-term region of FOXO3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXO3
Synonyms FKHRL1, FOXO3A
Function Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Cellular Location Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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This gene belongs to the forkhead family of transcriptionfactors which are characterized by a distinct forkhead domain. Thisgene likely functions as a trigger for apoptosis through expressionof genes necessary for cell death. Translocation of this gene withthe MLL gene is associated with secondary acute leukemia.Alternatively spliced transcript variants encoding the same proteinhave been observed.


Zhuo de, X., et al. J. Biol. Chem. 285(41):31491-31501(2010)Tudzarova, S., et al. EMBO J. 29(19):3381-3394(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Mikse, O.R., et al. Cancer Res. 70(15):6205-6215(2010)Chen, J., et al. PLoS ONE 5 (8), E12293 (2010) :

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$ 80.00
Cat# BP13306a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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