PIK3R4 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99570 |
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Clone Names | 100409034 |
Gene ID | 30849 |
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Other Names | Phosphoinositide 3-kinase regulatory subunit 4, PI3-kinase regulatory subunit 4, PI3-kinase p150 subunit, Phosphoinositide 3-kinase adaptor protein, PIK3R4 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13309c was selected from the Center region of PIK3R4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PIK3R4 |
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Synonyms | VPS15 {ECO:0000303|PubMed:23878393} |
Function | Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). |
Cellular Location | Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity) {ECO:0000250|UniProtKB:Q8VD65, ECO:0000305} |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
References
Matsunaga, K., et al. Nat. Cell Biol. 11(4):385-396(2009)Yan, Y., et al. Biochem. J. 417(3):747-755(2009)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Takeshita, F., et al. Semin. Immunol. 16(1):17-22(2004)Ligon, L.A., et al. Mol. Biol. Cell 14(4):1405-1417(2003)
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