|Other Names||Threonine aspartase 1, Taspase-1, 3425-, Threonine aspartase subunit alpha, Threonine aspartase subunit beta, TASP1, C20orf13|
|Target/Specificity||The synthetic peptide sequence is selected from aa 47-64 of HUMAN TASP1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor.
Hsieh, J.J., et al., Cell 115(3):293-303 (2003).
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