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TASP1 Blocking Peptide N-term
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H6P5 |
|---|---|
| Other Accession | Q8R1G1 |
| Gene ID | 55617 |
|---|---|
| Other Names | Threonine aspartase 1, Taspase-1, 3425-, Threonine aspartase subunit alpha, Threonine aspartase subunit beta, TASP1, C20orf13 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 47-64 of HUMAN TASP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TASP1 |
|---|---|
| Synonyms | C20orf13 |
| Function | Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor.
References
Hsieh, J.J., et al., Cell 115(3):293-303 (2003).
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