|Other Names||Neuropilin and tolloid-like protein 2, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, NETO2, BTCL2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13322a was selected from the N-term region of NETO2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a predicted transmembrane proteincontaining two extracellular CUB domains followed by a low-densitylipoprotein class A (LDLa) domain. It also has an intracellularFXNPXY-like motif, which has been shown in other proteins to beessential for the internalization of clathrin coated pits duringendocytosis. Alternatively spliced transcript variants have beenobserved, but they have not been fully characterized. [provided byRefSeq].
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Stohr, H., et al. Gene 286(2):223-231(2002)
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