|Other Names||Apolipoprotein O, Protein FAM121B, APOO, FAM121B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13324a was selected from the N-term region of APOO. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.|
|Cellular Location||Membrane; Single-pass membrane protein. Secreted|
|Tissue Location||Expressed in all tissues examined. Up- regulated in diabetic heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the apolipoprotein family.Members of this protein family are involved in the transport andmetabolism of lipids. The encoded protein associates with HDL, LDLand VLDL lipoproteins and is characterized by chondroitin-sulfateglycosylation. This protein may be involved in preventing lipidaccumulation in the myocardium in obese and diabetic patients.Alternative splicing results in multiple transcript variants.Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and16.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Lamant, M., et al. J. Biol. Chem. 281(47):36289-36302(2006)
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